Mathematical Modeling for Optimal Control of BK Virus Infection in Kidney Transplant Recipients
PI: Dr. Hien Tran (Professor of Mathematics and Director, CRSC)
Support: NIH (National Institute of Health)/Duke University.
Period of Performance: June 6th, 2023 – May 31st, 2024
Budget: $189,360
Summary: BK virus is a common infection of immune-suppressed kidney transplant patients, leading in some cases to loss of the transplanted kidney. There is no effective anti-viral against BK virus and the standard practice is to reduce immunosuppression, which can itself lead to kidney rejection; hence the management of immunosuppression of these patients is very challenging. We propose to use existing data sets from NIH-funded transplantation clinical trials to develop mathematical models and optimal control algorithms of the dynamic interactions between the virus, the immune systems, and the transplanted kidney and to build a software tool for personalized immunosuppression in these patients.